{"id":2155,"date":"2024-04-10T13:17:24","date_gmt":"2024-04-10T11:17:24","guid":{"rendered":"http:\/\/10.128.3.28\/?page_id=2155"},"modified":"2025-08-29T12:08:13","modified_gmt":"2025-08-29T10:08:13","slug":"proyecto-modelling-the-npc1-npc2-protein-protein-interaction-using-alphafold-multimer-and-molecular-dynamics-simulations","status":"publish","type":"page","link":"https:\/\/computaex.es\/en\/proyectos\/proyecto-modelling-the-npc1-npc2-protein-protein-interaction-using-alphafold-multimer-and-molecular-dynamics-simulations\/","title":{"rendered":"Modelling the NPC1-NPC2 protein-protein interaction using Alphafold Multimer and Molecular dynamics simulations"},"content":{"rendered":"<div class=\"field field-name-field-proy-investigadores field-type-text-long field-label-above\">\n<div class=\"field-label\" style=\"text-align: justify;\"><strong>Researchers:\u00a0<\/strong><\/div>\n<div class=\"field-items\" style=\"text-align: justify;\">\n<div class=\"field-item even\">\n<ul>\n<li>Llabr\u00e9s Prat.\u00a0<a href=\"https:\/\/www.ub.edu\/web\/portal\/es\/\">Universitat de Barcelona<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"field field-name-field-proy-descripcion field-type-text-long field-label-above\" style=\"text-align: justify;\">\n<div class=\"field-label\"><strong>Description:\u00a0<\/strong><\/div>\n<div class=\"field-items\">\n<div class=\"field-item even\">\n<p>Proyecto asignado a trav\u00e9s de la Red Espa\u00f1ola de Supercomputaci\u00f3n (<a href=\"https:\/\/www.res.es\/\" target=\"_blank\" rel=\"noopener\">RES<\/a>).<\/p>\n<p>Niemann-Pick disease type C is a rare genetic disorder in which cholesterol transport across the body is compromised. Its cause are mutations on the lysosomal NPC1 and NPC2 proteins. The aim of this project is to validate a structural model of the protein-protein interaction of NPC1 and NPC2 proteins using AlphaFold Multimer and state-of-the-art molecular modelling methods.<\/p>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Investigadores:\u00a0 Llabr\u00e9s Prat.\u00a0Universitat de Barcelona Descripci\u00f3n:\u00a0 Proyecto asignado a trav\u00e9s de la Red Espa\u00f1ola de Supercomputaci\u00f3n (RES). Niemann-Pick disease type C is a rare genetic disorder in which cholesterol transport &#8230;<\/p>","protected":false},"author":1,"featured_media":0,"parent":9950,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"categories":[103,81],"tags":[],"class_list":["post-2155","page","type-page","status-publish","hentry","category-ciencias-de-la-vida","category-proyectos"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Modelling the NPC1-NPC2 protein-protein interaction using Alphafold Multimer and Molecular dynamics simulations - Fundaci\u00f3n COMPUTAEX<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/computaex.es\/en\/proyectos\/proyecto-modelling-the-npc1-npc2-protein-protein-interaction-using-alphafold-multimer-and-molecular-dynamics-simulations\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Modelling the NPC1-NPC2 protein-protein interaction using Alphafold Multimer and Molecular dynamics simulations - Fundaci\u00f3n COMPUTAEX\" \/>\n<meta property=\"og:description\" content=\"Investigadores:\u00a0 Llabr\u00e9s Prat.\u00a0Universitat de Barcelona Descripci\u00f3n:\u00a0 Proyecto asignado a trav\u00e9s de la Red Espa\u00f1ola de Supercomputaci\u00f3n (RES). 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