{"id":2194,"date":"2024-04-10T13:26:46","date_gmt":"2024-04-10T11:26:46","guid":{"rendered":"http:\/\/10.128.3.28\/?page_id=2194"},"modified":"2025-08-29T11:58:36","modified_gmt":"2025-08-29T09:58:36","slug":"proyecto-genomic-signatures-of-homologous-recombination-defects-in-prostate-cancer","status":"publish","type":"page","link":"https:\/\/computaex.es\/en\/proyectos\/proyecto-genomic-signatures-of-homologous-recombination-defects-in-prostate-cancer\/","title":{"rendered":"Genomic signatures of homologous recombination defects in prostate cancer"},"content":{"rendered":"<div class=\"field field-name-field-proy-investigadores field-type-text-long field-label-above\">\n<div class=\"field-label\" style=\"text-align: justify;\"><strong>Researchers:\u00a0<\/strong><\/div>\n<div class=\"field-items\" style=\"text-align: justify;\">\n<div class=\"field-item even\">\n<ul>\n<li>Joaqu\u00edn Mateo. Vall d&#8217;Hebron Instituto of Oncology (<a href=\"https:\/\/www.vhio.net\/es\/\" target=\"_blank\" rel=\"noopener\">VHIO<\/a>).<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"field field-name-field-proy-descripcion field-type-text-long field-label-above\" style=\"text-align: justify;\">\n<div class=\"field-label\"><strong>Description:\u00a0<\/strong><\/div>\n<div class=\"field-items\">\n<div class=\"field-item even\">\n<p>Proyecto asignado a trav\u00e9s de la Red Espa\u00f1ola de Supercomputaci\u00f3n (<a href=\"https:\/\/www.res.es\/\" target=\"_blank\" rel=\"noopener\">RES<\/a>).<\/p>\n<p>Precision medicine is an unmet need in metastatic prostate cancer (mPC). PARP inhibitors are now approved for the treatment of mPC associated with HRR mutations; however, significant inter-patient variability in outcome exist; better predictive biomarkers for patient stratification are needed. Genomic signatures of HRR defects have putative predictive value in other tumor types, but their clinical significance in prostate cancer is unknown. We will study the distribution of genomic events associated to HRR defects (LOH, LST, NTAI, CNA patterns) and derived signatures. We will test the hypothesise, based on data from our lab, that these signatures are enriched with resistance to hormonal treatments. We will study these features in WES and WGS datasets covering the disease spectrum, from treatment-na\u00efve to late-stage drug resistant mPC.<\/p>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Investigadores:\u00a0 Joaqu\u00edn Mateo. Vall d&#8217;Hebron Instituto of Oncology (VHIO). Descripci\u00f3n:\u00a0 Proyecto asignado a trav\u00e9s de la Red Espa\u00f1ola de Supercomputaci\u00f3n (RES). Precision medicine is an unmet need in metastatic prostate &#8230;<\/p>","protected":false},"author":1,"featured_media":0,"parent":9950,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"categories":[103,81],"tags":[],"class_list":["post-2194","page","type-page","status-publish","hentry","category-ciencias-de-la-vida","category-proyectos"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Genomic signatures of homologous recombination defects in prostate cancer - Fundaci\u00f3n COMPUTAEX<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/computaex.es\/en\/proyectos\/proyecto-genomic-signatures-of-homologous-recombination-defects-in-prostate-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Genomic signatures of homologous recombination defects in prostate cancer - Fundaci\u00f3n COMPUTAEX\" \/>\n<meta property=\"og:description\" content=\"Investigadores:\u00a0 Joaqu\u00edn Mateo. Vall d&#8217;Hebron Instituto of Oncology (VHIO). Descripci\u00f3n:\u00a0 Proyecto asignado a trav\u00e9s de la Red Espa\u00f1ola de Supercomputaci\u00f3n (RES). 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