{"id":2204,"date":"2024-04-10T13:28:18","date_gmt":"2024-04-10T11:28:18","guid":{"rendered":"http:\/\/10.128.3.28\/?page_id=2204"},"modified":"2025-08-29T11:57:25","modified_gmt":"2025-08-29T09:57:25","slug":"proyecto-investigating-the-effects-of-disease-causing-mutations-on-the-stability-and-dynamic-properties-of-the-human-hint1-protein","status":"publish","type":"page","link":"https:\/\/computaex.es\/en\/proyectos\/proyecto-investigating-the-effects-of-disease-causing-mutations-on-the-stability-and-dynamic-properties-of-the-human-hint1-protein\/","title":{"rendered":"Investigating the effects of disease-causing mutations on the stability and dynamic properties of the human Hint1 protein"},"content":{"rendered":"<div class=\"field field-name-field-proy-investigadores field-type-text-long field-label-above\">\n<div class=\"field-label\" style=\"text-align: justify;\"><strong>Researchers:\u00a0<\/strong><\/div>\n<div class=\"field-items\" style=\"text-align: justify;\">\n<div class=\"field-item even\">\n<ul>\n<li>Shoshana Wodak.\u00a0<a href=\"https:\/\/\/en\/vib.be\/vib-vub-center-structural-biology\/\" target=\"_blank\" rel=\"noopener\">VIB-VUB Center for Structural Biology<\/a>.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"field field-name-field-proy-descripcion field-type-text-long field-label-above\" style=\"text-align: justify;\">\n<div class=\"field-label\"><strong>Description:\u00a0<\/strong><\/div>\n<div class=\"field-items\">\n<div class=\"field-item even\">\n<p>Proyecto asignado a trav\u00e9s de la Red Espa\u00f1ola de Supercomputaci\u00f3n (<a href=\"https:\/\/www.res.es\/\" target=\"_blank\" rel=\"noopener\">RES<\/a>).<\/p>\n<p>Mutations of the dimeric Hint1 enzyme are well-known to cause neuropathy associated with neuromyotonia (NMAN). So far, 25 distinct NMAN causative variants have been identified world-wide. Structure-based bioinformatics predictors and in vivo assays revealed that certain variants compromise the protein stability more than the others. In this molecular dynamics (MD) simulation study, we scrutinize the structural dynamics of the wild-type and the single-residue mutant constructs, moreover, the extent of the destabilization effect of disease variants by MD simulations and thermodynamic integration in order to find disease variants that only compromise the stability to the extent that it is rescuable by small molecule stabilizers.<\/p>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Investigadores:\u00a0 Shoshana Wodak.\u00a0VIB-VUB Center for Structural Biology. Descripci\u00f3n:\u00a0 Proyecto asignado a trav\u00e9s de la Red Espa\u00f1ola de Supercomputaci\u00f3n (RES). Mutations of the dimeric Hint1 enzyme are well-known to cause neuropathy &#8230;<\/p>","protected":false},"author":1,"featured_media":0,"parent":9950,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"categories":[103,81],"tags":[],"class_list":["post-2204","page","type-page","status-publish","hentry","category-ciencias-de-la-vida","category-proyectos"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Investigating the effects of disease-causing mutations on the stability and dynamic properties of the human Hint1 protein - Fundaci\u00f3n COMPUTAEX<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/computaex.es\/en\/proyectos\/proyecto-investigating-the-effects-of-disease-causing-mutations-on-the-stability-and-dynamic-properties-of-the-human-hint1-protein\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigating the effects of disease-causing mutations on the stability and dynamic properties of the human Hint1 protein - Fundaci\u00f3n COMPUTAEX\" \/>\n<meta property=\"og:description\" content=\"Investigadores:\u00a0 Shoshana Wodak.\u00a0VIB-VUB Center for Structural Biology. 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