{"id":2216,"date":"2024-04-10T13:30:49","date_gmt":"2024-04-10T11:30:49","guid":{"rendered":"http:\/\/10.128.3.28\/?page_id=2216"},"modified":"2025-08-29T11:58:36","modified_gmt":"2025-08-29T09:58:36","slug":"proyecto-functional-dynamics-of-human-dna-polymerase-delta","status":"publish","type":"page","link":"https:\/\/computaex.es\/en\/proyectos\/proyecto-functional-dynamics-of-human-dna-polymerase-delta\/","title":{"rendered":"Functional dynamics of human DNA polymerase delta"},"content":{"rendered":"<div class=\"field field-name-field-proy-investigadores field-type-text-long field-label-above\">\n<div class=\"field-label\" style=\"text-align: justify;\"><strong>Researchers:\u00a0<\/strong><\/div>\n<div class=\"field-items\" style=\"text-align: justify;\">\n<div class=\"field-item even\">\n<ul>\n<li>Ramon Crehuet. Consejo Superior de Investigaciones Cient\u00edficas (<a href=\"https:\/\/www.csic.es\/\" target=\"_blank\" rel=\"noopener\">CSIC<\/a>)<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"field field-name-field-proy-descripcion field-type-text-long field-label-above\" style=\"text-align: justify;\">\n<div class=\"field-label\"><strong>Description:\u00a0<\/strong><\/div>\n<div class=\"field-items\">\n<div class=\"field-item even\">\n<p>Proyecto asignado a trav\u00e9s de la Red Espa\u00f1ola de Supercomputaci\u00f3n (<a href=\"https:\/\/www.res.es\/\" target=\"_blank\" rel=\"noopener\">RES<\/a>).<\/p>\n<p>Although the basic process of DNA replication is well-known, there are still many questions about the roles of specific components and how is the high fidelity of the replication achieved. One of these components is p12, a protein that binds DNA polymerase delta and regulates its activity. In the present work we aim to understand how p12 modulates the activity of its partner polymerase delta by combining structures from Cryo-EM and enhanced sampling simulations. Our hypothesis is that this small protein is able to control the rate at which polymerase delta changes from active to inactive conformations by binding to a critical region of the polymerase.<\/p>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Investigadores:\u00a0 Ramon Crehuet. Consejo Superior de Investigaciones Cient\u00edficas (CSIC) Descripci\u00f3n:\u00a0 Proyecto asignado a trav\u00e9s de la Red Espa\u00f1ola de Supercomputaci\u00f3n (RES). Although the basic process of DNA replication is well-known, &#8230;<\/p>","protected":false},"author":1,"featured_media":0,"parent":9950,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"categories":[103,81],"tags":[],"class_list":["post-2216","page","type-page","status-publish","hentry","category-ciencias-de-la-vida","category-proyectos"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Functional dynamics of human DNA polymerase delta - Fundaci\u00f3n COMPUTAEX<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/computaex.es\/en\/proyectos\/proyecto-functional-dynamics-of-human-dna-polymerase-delta\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Functional dynamics of human DNA polymerase delta - Fundaci\u00f3n COMPUTAEX\" \/>\n<meta property=\"og:description\" content=\"Investigadores:\u00a0 Ramon Crehuet. Consejo Superior de Investigaciones Cient\u00edficas (CSIC) Descripci\u00f3n:\u00a0 Proyecto asignado a trav\u00e9s de la Red Espa\u00f1ola de Supercomputaci\u00f3n (RES). 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Consejo Superior de Investigaciones Cient\u00edficas (CSIC) Descripci\u00f3n:\u00a0 Proyecto asignado a trav\u00e9s de la Red Espa\u00f1ola de Supercomputaci\u00f3n (RES). 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