{"id":2233,"date":"2024-04-10T13:35:45","date_gmt":"2024-04-10T11:35:45","guid":{"rendered":"http:\/\/10.128.3.28\/?page_id=2233"},"modified":"2025-08-29T12:14:49","modified_gmt":"2025-08-29T10:14:49","slug":"proyecto-understanding-a-novel-mode-of-non-canonical-cam-activation","status":"publish","type":"page","link":"https:\/\/computaex.es\/en\/proyectos\/proyecto-understanding-a-novel-mode-of-non-canonical-cam-activation\/","title":{"rendered":"Understanding a novel mode of non-canonical CaM activation"},"content":{"rendered":"<div class=\"field field-name-field-proy-investigadores field-type-text-long field-label-above\">\n<div class=\"field-label\" style=\"text-align: justify;\"><strong>Researchers:\u00a0<\/strong><\/div>\n<div class=\"field-items\" style=\"text-align: justify;\">\n<div class=\"field-item even\">\n<ul>\n<li>Alvaro Villarroel.\u00a0<a href=\"https:\/\/www.biofisika.org\/es\" target=\"_blank\" rel=\"noopener\">Insituto Biofisika<\/a>\u00a0(Basque Centre for Biophysics), CSIC, UPV\/EHU.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"field field-name-field-proy-descripcion field-type-text-long field-label-above\">\n<div class=\"field-label\" style=\"text-align: justify;\"><strong>Description:\u00a0<\/strong><\/div>\n<div class=\"field-items\">\n<div class=\"field-item even\">\n<p style=\"text-align: justify;\">Proyecto asignado a trav\u00e9s de la Red Espa\u00f1ola de Supercomputaci\u00f3n (<a href=\"https:\/\/www.res.es\/\" target=\"_blank\" rel=\"noopener\">RES<\/a>).<\/p>\n<p style=\"text-align: justify;\">Calmodulin (CaM) is the main eukaryotic mediator that confers the ability to respond to intracellular Ca2+ oscillations. CaM binds a huge amount of targets and transmit the Ca2+ signalization in a versatile way, making it a suitable pharmacological target. We are investigating and interaction between a peptide and CaM, which is able to modulate de calcium signal into the cellar excitability dampener Kv7 channel. The aim of this project is to translate the wet experiments to in silico systems to describe at an atomic level how different peptides interact with CaM and translate the calcium signalling to proteins. We believe that this non-canonical mechanism of calcium modulation will provide insights to develop new drug applicable to several diseases, such as, epileptogenic epilepsy and Amyotrophic Lateral Sclerosis (ALS).<\/p>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Investigadores:\u00a0 Alvaro Villarroel.\u00a0Insituto Biofisika\u00a0(Basque Centre for Biophysics), CSIC, UPV\/EHU. Descripci\u00f3n:\u00a0 Proyecto asignado a trav\u00e9s de la Red Espa\u00f1ola de Supercomputaci\u00f3n (RES). Calmodulin (CaM) is the main eukaryotic mediator that confers &#8230;<\/p>","protected":false},"author":1,"featured_media":0,"parent":9950,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"categories":[103,81],"tags":[],"class_list":["post-2233","page","type-page","status-publish","hentry","category-ciencias-de-la-vida","category-proyectos"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Understanding a novel mode of non-canonical CaM activation - Fundaci\u00f3n COMPUTAEX<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/computaex.es\/en\/proyectos\/proyecto-understanding-a-novel-mode-of-non-canonical-cam-activation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Understanding a novel mode of non-canonical CaM activation - Fundaci\u00f3n COMPUTAEX\" \/>\n<meta property=\"og:description\" content=\"Investigadores:\u00a0 Alvaro Villarroel.\u00a0Insituto Biofisika\u00a0(Basque Centre for Biophysics), CSIC, UPV\/EHU. 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